Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Genetic recombination as DNA repair

Maintenance of sexual reproduction and genetic recombination imposes physiological costs when compared to parthenogenic reproduction, most prominently: for maintaining the corresponding (molecular) machinery, for finding a mating partner, and through the decreased fraction of females in a population, which decreases the reproductive capacity. Based on principles from information theory, we have...

DNA Repair Pathways and Mechanisms

Our cells are constantly exposed to insults from endogenous and exogenous agents that can introduce damage into our DNA and generate genomic instability. Many of these lesions cause structural damage to DNA and can alter or eliminate fundamental cellular processes, such as DNA replication or transcription. DNA lesions commonly include base and sugar modifications, singleand double-strand breaks...

Plant DNA repair and recombination on the French Mediterranean. Workshop on plant DNA repair & recombination.

Nickel Increases Chromosomal Abnormalities by Interfering with the Initiation of DNA Repair Pathways

Background: Nickel is a carcinogenic, heavy metal released through industrial activities and via natural resources. It is able to cause DNA damages by reducing the efficiency of DNA repair mechanisms. However, the exact time point at which it is able to interfere with these mechanisms is not yet clearly understood. Methods: To find the most nickel-vulnerable time of repair mechanisms, human de...

Genome Stability: DNA Repair and Recombination

Gene Control, second edition, is a concise book that focuses on gene expression and regulation in eukaryotes. Synonymous with the first edition, the chapters build on themselves, culminating in a discussion correlating gene control in regard to human health and disease. The author uses illustrations where appropriate, focusing on simplistic figures that correlate DNA, RNA, and regulatory protei...